In-Line and Real-Time Bioprocess Raman Analyzer
ProCellics™ is the first GMP Bioprocess Raman Analyzer for the biopharmaceutical industry fully dedicated to in-line monitoring of the critical parameters and quality attributes in real-time, in order to maintain an optimal development of cultures in bioreactors and to better control downstream processes.
Thanks to ProCellics™, it is now possible to easily implement a GMP Process Analytical Technology solution for upstream and downstream processes!
In-line analytical monitoring inside the bioreactor
Real-time display / OPC transfer of quantified parameters
Easy multivariate calibration with ProCellics™ Software / SIMCA®
GMP immersion probe of 12 mm diameter adapted to PG 13.5 / M 18 bioreactor port
IP65 compact analyzer unit
CFR 21 part 11 facilitated
Multi-channel unit to operate up to 4 probes from a single analyzer (option)
ProCellics™ easy model-building and real-time monitoring
ProCellics™ Software offers 4 modules:
Maintenance & Settings
The architecture of the software has been defined to be clear, to offer guidelines for non-experts and to facilitate compliance with CFR 21 part 11 guidance.
The proper methodology implemented in ProCellics™ Software allows to easily design robust chemometrics models to be used in subsequent routine batch monitoring. This methodology is ideally suited to the feeding strategy optimization (feeding of glucose, medium, etc.), makes the implementation accessible to non-experts, and demonstrates the robustness of your model.
The dataset used for the multivariate calibration is prepared in ProCellics™ software. The models are generated in SIMCA® and the monitoring module of ProCellics™ uses an integrated BioPAT® SIMCA-Q (Powered by Sartorius Stedim Data Analytics AB) engine to execute the models in real-time.
Multi-channel unit option
Operate up to 4 probes from a single analyzer
Analyzer unit add-on with no impact on the system footprint
Single software interface
Sequential measurement of the same or different processes
User-friendly interface to manage probes’ parameters, timing and traceability
Probe instrumental calibration features to easily allow model building with mixed data from different probes
Fast 1st multivariate calibration with multiple parallel batches
Robust models catching setup variability to ease transfer between devices
Even more affordable cost per measurement point
Better understanding of bioprocesses
Improved batch monitoring
Continuous quality control
Reduced risk of batch failure
Optimized production yield/capacity
Faster Development &
Enhanced Process Productivity
This PAT tool will increase your site productivity, facilitating Quality By Design